TRABAJOS PUBLICADOS

 

• Apoptotic cell death induced by dendritic derivatives of aminolevulinic acid in endothelial and foam cells co-cultures. M. Céspedes, D. Saénz, G. Calvo, M. González, A. MacRobert, S. Battah, A. Casas* & G. Di Venosa. Photochem. Photobiol. Sci. 20:489-499 (2021).  LINK  

 

• Photosensitization of a subcutaneous tumour by the natural anthraquinone parietin and blue light.  María Laura Mugas, Gustavo Calvo, Juliana Marioni, Mariela Céspedes, Florencia Martinez, Silvia Vanzulli, Daniel Sáenz, Gabriela Di Venosa, Susana Nuñez Montoya & Adriana Casas  Scientific Reports volume 11, Article number: 23820 (2021) LINK  

 

• Photodynamic therapy of cutaneous T-cell lymphoma cell lines mediated by 5-aminolevulinic acid and derivatives. P. Vallecorsa, G. Di Venosa, G. Gola, D. Sáenz, L. Mamone, A.J. MacRobert, J. Ramírez & A.Casas. J. Photochem. Photobiol B: Biol. 221:112244-50 (2021). LINK  

 

• Novel meso-substituted porphyrin derivatives and its potential use in photodynamic therapy of cancer.   P. Vallecorsa, G. Di Venosa, M. B. Ballatore, D. Ferreyra, L. Mamone, D. Sáenz, E. Durantini & A. Casas. BMC Cancer 21:547 (2021). doi.org/10.1186/s12885-021-08286-6  LINK 

• Synthesis and cytotoxicity evaluation of olivacine-indole hybrids tethered by alkyl linkers. C. Pis Diez, M. Céspedes, G. Di Venosa, G. Calvo, E. Avigliano, A. Casas, J. Palermo. Nat. Prod. Res. Feb 1;1-8 (2021).    DOI: 10.1080/14786419.2021.1880401

 

• Photodynamic therapy of tumour cells mediated by the natural antraquione parietin and blue light. M. L. Laura Mugas, G. Calvo, J. Marioni, M. Céspedes, F. Martinez, D. Sáenz, G. Di Venosa, J.L. Cabrera, S. Nuñez Montoya, A.Casas. J. Photochem. Photobiol B: Biol . 214:112089 (2021). LINK  

 

• Fluorescent labeling of lipid droplets from cultured cells by reduced phenazine methosulfate. J. C. Stockert, M.C. Carou, A. Casas, M. C. García Vior, S. Ezquerra Riega, M. Blanco, J. Espada, A. Blázquez-Castro, R.W. Horobin, D. Lombardo. Heliyon, 6: e04182 (2020). LINK

  

• Clinical uses of 5-aminolaevulinic acid in photodynamic treatment and photodetection of cancer: a review. A. Casas . Can. Letters, 490:165-17310 (2020) 1016/j.canlet.2020.06.008.

 

•  Photodynamic inactivation mediated by 5-aminolevulinic acid of bacteria in planktonic and biofilm forms. G. Cervini Bohm, L. Gándara, G. Di Venosa, L. Mamone, F. Buzzola & A. Casas. Biochem. Pharmacol. 177:114016 (2020).

• Bacterial viability after antimicrobial photodynamic therapy with Curcumin on multiresistant Staphylococcus aureus. M. Alves Freitas, A. Correia Pereira, J. Guerra Pinto, A. Casas, J. Ferreira-Strixino. Fut. Microbiol. 14:739-748 (2019)

• Disaccharides obtained from carrageenans as potential antitumor agents. Calvo GH, Cosenza VA, Sáenz DA, Navarro DA, Stortz CA, Céspedes MA, Mamone LA, Casas AG, Di Venosa GM. Sci Rep. 9:6654  (2019). LINK

  

• One-step preparation of novel 1-(N-indolyl)-1,3- butadienes by base-catalysed isomerization of alkynes as an access to 5-(N-indolyl)- naphthoquinones C. M. Pis Diez, J. F. Fernandez, G. Di Venosa, A. Casas, R. Pis Diez and J. A. Palermo. RSC Adv. 8: 35998 (2018).

 

• Synthesis and cytotoxicity evaluation of A-ring derivatives of cycloartanone. Zambrano E., Casas A.,  Di Venosa G., Uriburu N.L., Duran F.,  Palermo A. Phytochem. Lett. 21: 200-205 (2017).

 

• Enhancement of photodynamic inactivation of Staphylococcus aureus biofilms by disruptive strategies. Gándara L, Mamone L, Bohm GC, Buzzola F, Casas A. Lasers Med Sci. 32:1757-1767 (2017).

 

• Reversal of the migratory and invasive phenotype of Ras-transfected mammary cells by photodynamic therapy treatment. Calvo G., Sáenz D., Simian M., Sampayo R., Mamone L., Vallecorsa P., Batlle A., Casas A. & Di Venosa G.  J. Cell Physiol. 118:464-477 (2017).

 

• Sae regulator factor impairs the response to photodynamic inactivation mediated by Toluidine blue in Staphylococcus aureus. L. Gándara, L. Mamone, C. Dotto, F. Buzzola & A. Casas.  Photodiagnos. Photodyn. Ther. 16:136-141 (2016).

 

• Synthesis of chemically diverse esters of 5-aminolevulinic acid for photodynamic therapy via the multicomponent Passerini reaction. G.Gola, G. Di Venosa, D. Sáenz, G. Calvo, G.Cabrera, A. Casas, J. Ramírez. RSC Adv. 6, 89492-89498 (2016).

 

• Methods for the detection of reactive oxygen species employed in the identification of plant photosensitizers. L. Mamone; G. Di Venosa; D. Saenz; A. Batlle; A. Casas.  Methods 109:73-80 (2016).

 

• Photodynamic inactivation of planktonic and biofilm growing bacteria mediated by a meso-substituted porphyrin bearing four basic amino groups. L. Mamone, D. D. Ferreyra, L. Gándara, G. Di Venosa, P. Vallecorsa, D. Sáenz, Gustavo Calvo, A. Batlle, F. Buzzola, E. N. Durantini & A. Casas. Photochem Photobiol B Biol 161:222-9 (2016).

 

• Aminolevulinic acid dendrimers in photodynamic treatment of cancer and atheromatous disease. L. Rodriguez,   P. Vallecorsa,   S. Battah,   G. Di Venosa,   G. Calvo,   L. Mamone,   D. Sáenz,   M. Gonzalez,   A. Batlle,   A. MacRobert  & A. Casas. Photochem. Photobiol. Sci., 14:1617-27 (2015). 

 

• Di Venosa G.,  Perotti C., Batlle A. &  Casas A.  The role of cytoskeleton and adhesion proteins in the resistance to Photodynamic Therapy. Possible therapeutic interventions. Photochem. Photobiol. Sci.,14:1451-64 (2015).

 

• The Use of Dipeptide Derivatives of 5-Aminolaevulinic Acid Promotes Their Entry to Tumor Cells and Improves Tumor Selectivity of Photodynamic Therapy. Venosa GD, Vallecorsa P, Giuntini F, Mamone L, Batlle A, Vanzuli S, Juarranz A, MacRobert AJ, Eggleston IM & Casas A. Mol Cancer Ther. 14:440-451 (2015). LINK

 

• Photosensitizing effect of Argentinean plant extracts on Gram-positive bacteria. Mamone, G. Di Venosa, L. Gándara, D. Sáenz, P. Vallecorsa, S. Schickinger, M. V. Rossetti, A. Batlle, F. Buzzola & A. Casas. J. Photochem. Photobiol. B Biol 133: 80-89 (2014).

 

• The natural flavonoid silybin improves the response to Photodynamic Therapy of bladder cancer cells. L. Gandara, E. Sandes, G. Di Venosa, B. Prack Mc Cormick, L. Rodriguez, L. Mamone, A. Batlle, A.M. Eiján, A. Casas. J. Photochem. Photobiol. B Biol,133: 55-64 (2014).

 

• Photoprotective Effect of the Plant Collaea argentina against Adverse Effects Induced by Photodynamic Therapy.L. Mamone, D. Sáenz, P. Vallecorsa, A. Batlle, A. Casas, & G. Di Venosa.  Int. J. Photoenergy, Volume 2014 (2014), Article ID 436463. http://dx.doi.org/10.1155/2014/436463.

 

• Light fractionated ALA-PDT enhances therapeutic efficacy in vitro; the influence of PpIX concentration and illumination parameters. de Bruijn HS, Casas AG, Di Venosa G, Gandara L, Sterenborg HJ, Batlle A, Robinson DJ. Photochem Photobiol Sci. 12: 241-245 (2013).

 

• Changes in actin and E-cadherin expression induced by 5-aminolevulinic acid photodynamic therapy in normal and Ras-transfected human mammary cell lines. Di Venosa G, Rodriguez L, Mamone L, Gándara L, Rossetti MV, Batlle A, Casas A. J Photochem Photobiol B. 106:47-52 (2012).

 

• Mechanisms of resistance to Photodynamic Therapy. Casas A. Di Venosa G, Hasan H & Batlle A. Curr. Med Chem. 18:2486-2515 (2011). LINK 

 

• Cytotoxic effects of Argentinian plant extracts on tumor and normal cell lines.  Mamone L., Di Venosa G., Valla J., Rodriguez L., Gándara L., Batlle A.,  Heinrich M., Juarranz A., Sanz- Rodriguez F., Casas A. Cell. Mol. Biol. (Noisy-le-grand)57 Suppl:OL1487-99 (2011).

 

• Comparison of liposomal formulations of ALA Undecanoyl ester for its use in photodynamic therapy. Di Venosa G, Hermida L, Fukuda H, Defain MV, Rodriguez L, Mamone L, MacRobert A, Casas A, Batlle A. J Photochem Photobiol B., 96:152-158 (2009). 

 

• Porphyrin synthesis from aminolevulinic acid esters in endothelial cells and its role in photodynamic therapy. Rodriguez L, de Bruijn HS, Di Venosa G, Mamone L, Robinson DJ, Juarranz A, Batlle A, Casas A. J Photochem Photobiol B. 2009  96:249-254 (2009).

 

• Sustained and efficient porphyrin generation in vivo using dendrimer conjugates of 5-ALA for photodynamic therapy. Casas A, Battah S, Di Venosa G, Dobbin P, Rodriguez L, Fukuda H, Batlle A, Macrobert AJ.  J Control. Release 135:136-143 (2009).

 

• Decreased metastatic phenotype in cells resistant to Aminolevulinic acid-Photodynamic therapy. Casas A, Di Venosa G, Vanzulli S, Perotti C, Mamome L, Rodriguez L, Simian M, Juarranz A, Pontiggia O, Hasan T, Batlle A.  Cancer Lett.  271:342-51 (2008). LINK

• Characterisation of liposomes containing aminolevulinic acid and derived esters. Di Venosa G, Hermida L, Batlle A, Fukuda H, Defain MV, Mamone L, Rodriguez L, Macrobert A, Casas A. J Photochem Photobiol B., 92:1-9 (2008).

 

• Disorganisation of cytoskeleton in cells resistant to photodynamic treatment with decreased metastatic phenotype. Casas A, Sanz-Rodriguez F, Di Venosa G, Rodriguez L, Mamone L, Blázquez A, Jaén  P, Batlle A, Stockert JC, Juarranz A.  Cancer Lett. 270:56-65 (2008).

 

• Response to ALA-based PDT in an immortalised normal breast cell line and its counterpart transformed with the Ras oncogene. Rodríguez L., DiVenosa G., Batlle A., MacRobert A. & Casas A. Photochem. Photobiol. Sci., 6, 1306 – 1310 (2007).

 

• Macromolecular delivery of 5-aminolaevulinic acid for photodynamic therapy using dendrimer conjugates. Battah S, Balaratnam S, Casas A, O'Neill S, Edwards C, Batlle A, Dobbin P, MacRobert AJ. Mol. Cancer Ther. 6: 876-85 (2007).

 

• Photodynamic therapy in Argentina. Casas A. & Batlle A. Photodiagnosis and Photodynamic Therapy, 3: 205-213 (2006).

 

• Tumor cell lines resistant to ALA-mediated Photodynamic Therapy and possible tools to target surviving cells. Casas A, Perotti C, Ortel B, Di Venosa G, Saccoliti M, Batlle A & Hasan T. Int. J. Oncol. 29:397-405 (2006).

 

• Distribution of 5-aminolevulinic acid derivatives and induced porphyrin kinetics in mice tissues. Di Venosa G, Batlle A, Fukuda H, MacRobert A & Casas A. Cancer Chemother. Pharmacol. 58: 478-486 (2006).

 

• Aminolevulinic acid derivatives and liposome delivery as strategies for improving 5-aminolevulinic acid-mediated photodynamic therapy. Casas A, Batlle A. Curr. Med. Chem., 13:1157-68 (2006). 

 

• Study of the mechanisms of uptake of 5-aminolevulinic acid derivatives by PEPT1 and PEPT2 transporters as a tool to improve photodynamic therapy of tumours. Rodriguez L, Batlle A, Di Venosa G, Macrobert AJ, Battah S, Daniel H, Casas A. Int J Biochem Cell Biol.,38:1530-9 (2006). 

 

• Mechanisms of uptake of  5-aminolevulic acid esters in mammalian cells. Rodríguez L,  Batlle A, Di Venosa G, Battah S, Dobbin P, MacRobert A & Casas A.  Br. J. Pharmacol. 147: 825-833 (2006). LINK

• Photodynamic therapy: Regulation of porphyrin synthesis and hydrolysis from ALA esters. Di Venosa G, Fukuda H, Batlle A, Macrobert A, Casas A. J Photochem Photobiol B. 83:129-36 (2006). 

 

• Investigation of a novel dendritic derivative of 5-aminolaevulinic acid for photodynamic therapy. Di Venosa G, Casas A., Battah S, Dobbin P, Fukuda H, MacRobert A, Batlle A.  Int. J. Biochem. Cell Biol., 38: 82-91 (2006).

 

• The use of ALA and ALA derivatives for optimizing ALA-based Photodynamic Therapy: a review of our experience. Fukuda H, Casas A & Batlle A.  J. Environm. Pathol. Toxicol. Oncol., 25: 127-144 (2006).

 

• No cross resistance between ALA-PDT and Nitric Oxide. Di Venosa G, Casas A, Fukuda H, Perotti C & Batlle A. Nitric Oxide, 13: 155-162.(2005).

 

• Sensitivity to ALA-PDT of cell lines with different nitric oxide production and resistance to nitric oxide cytotoxicity.  Di Venosa G, Perotti C, Fukuda H, Batlle A & Casas A. J.Photochem. Photobiol. B, 80: 195-202 (2005).

 

• Aminolevulinic acid: from its unique biological function to its star role in photodynamic therapy.  Fukuda H, Casas A &  Batlle A.  Int. J. Biochem. Cell Biol, 37: 272-276 (2005).

 

• A method for separating ALA from ALA derivatives using ionic exchange chromatography. Di Venosa G, Fukuda H, Perotti C, Batlle A & Casas A.  J. Photochem. Photobiol B.,75:157-63 (2004).

 

• Porphyrin synthesis from ALA derivatives for Photodynamic therapy. In vitro and in vivo studies.  Perotti C, Fukuda H, Di Venosa G, MacRobert A, Batlle A & Casas A.  Br J. Cancer, 90: 1660-1665 (2004). LINK

• Mechanistic studies on 5-aminolevulinic acid uptake and efflux in a mammary adenocarcinoma cell line.  Correa García S, Casas A, Perotti C, Batlle A & Bermúdez Moretti M.  Br. J. Cancer, 89: 173-177 (2003). 

 

• Topical application of ALA and ALA hexyl ester on a subcutaneous mammary adenocarcinoma: tissue distribution.  Perotti C, Casas A, Fukuda H, Sacca P & Batlle A.  Br J. Cancer , 88: 432-437 (2003). 

 

• In vitro photosensitisation of a murine mammary adenocarcinoma with Verteporfin. Casas A, Di Venosa G, Batlle A & Fukuda H. Cell. mol. Biol, 48: 931-937 (2002). 

 

• ALA and ALA hexyl ester induction of porphyrins after their systemic administration to tumour bearing mice. Perotti C, Casas A, Fukuda H, Sacca P & Batlle A.  Br. J. Cancer, 87: 790-795 (2002). 

 

• d-aminolevulinic acid transport in mammary adenocarcinoma cells is mediated by beta transporters. Bermúdez Moretti M, Correa García S, Perotti C, Batlle A and Casas A. Br. J. Cancer, 87: 471-474 (2002). 

 

• Rational design of  5-aminolevulinic acid derivatives aimed at improving Photodynamic Therapy.  Casas A & Batlle A. Curr Med. Chem. Anti-Cancer Agents, 2: 465-475 (2002). 

 

• Scavengers protection of cells against ALA-based Photodynamic Therapy-induced damage.  Perotti C,  Fukuda H,  Casas A & Batlle A. Lasers Med. Sci, 17: 229-229 (2002).

 

• ALA and ALA hexyl ester in free and liposomal formulations for the photosensitisation of tumour organ cultures” Casas A,  Perotti C,  Saccoliti M,  Sacca P,  Fukuda H &  Batlle A.  Br J. Cancer, 86: 837-842 (2002).

 

• Photodynamic Therapy of activated and resting lymphocytes and its antioxidant adaptive response. Casas A, Perotti C,  Fukuda H &  Batlle A. Lasers Med. Sci. 17: 42-50 (2002).

 

• ALA and ALA hexyl ester-induced porphyrin synthesis in chemically induced skin tumours: the role of different vehicles on improving photosensitisation. Casas A, Perotti C, Fukuda H, Rogers L, Butler A &  Batlle A. Br J. Cancer, 85: 1740-1800 (2001).

 

• Photosensitisation and mechanism of cytotoxicity induced by the use of ALA derivatives in photodynamic therapy. Casas A, Fukuda H, Di Venosa G & Batlle A.  Br J. Cancer 85: 279-284 (2001). LINK

 

• Terapia fotodinámica en el tratamiento de tumores de piel inducidos químicamente. Casas A, DiVenosa G, Casentini C, Meiss R, Vanzulli S, Fukuda H & Batlle A.  Rev. Argent. Dermatol., 81: 144-152 (2000).

 

• The influence of the vehicle on the synthesis of porphyrins after topical application of ALA.  Implications  in cutaneous photodynamic sensitization.  Casas A, Fukuda H & Batlle A.  Br J. Dermatol. 143: 564-572 (2000).

 

• Tissue distribution and kinetics of endogenous porphyrins synthesized after topical application of ALA in different vehicles. Casas A, Fukuda H, & Batlle A.   Br. J. Cancer, 81, 13-18  (1999).

 

• Comparative effect of ALA derivatives on Protoporphyrin IX production in human and rat skin organ cultures. Casas A, Batlle A, Butler A, Robertson D,  MacRobert A & Riley P. Br. J.Cancer, 80, 1525-1532 (1999).

 

• Topical and intratumoural Photodynamic Therapy with 5-aminolevulinic acid in a subcutaneous murine mammary adenocarcinoma.  Casas A, Fukuda H, Meiss R & Batlle A.  Cancer Lett. 141, 29-38 (1999).

 

• Potentiation of the 5-aminolevulinic acid-based photodynamic therapy with cyclophosphamide. Casas A, Fukuda H & Batlle A.  Cancer Biochem. Biophys, 16,  183-196 (1998).

 

• Enhancement of Aminolevulinic Acid based photodynamic therapy by Adriamycin. Casas A, Fukuda H, Riley P & Batlle A.  Cancer Lett., 121, 105-113 (1997).

 

• Metabolic changes driven by cyclophosphamide treatment in mice.  Casas A, Fukuda H & Batlle A.  Cell. mol. Biol., 43, 95-101 (1997).

 

• Photodynamic action of endogenously synthesized porphyrins from aminolevulinic acid, using a new model for assaying the effectiveness of tumoral cell killing.  Fukuda H, Casas A, Chueke F, Paredes S & Batlle A.  Int. J. Biochem., 25, 1395‑1398 (1993).

 

• Potential of liposome-entrapped aminolevulinic acid in cancer therapy.  Effect of prior injection of empty liposomes and different routes of administration. Fukuda H, Paredes S,  Casas A, Chueke F, &  Batlle A.  The Cancer Journal, 5,  295‑299 (1992)